Clomid is currently appreciated and approved as an effective non-steroidal fertility drug, which stimulates the functioning of the pituitary gland, which releases the hormone required for ovulation occurrence. The drug was first introduced in 1956 by Frank Palopoli and his team at William S. Merrell Chemical Company. The first successful ovulation induction associated with Clomid use dates back to 1961 with its further approval by the Food and Drug Administration in 1967. Originally, the medication was used in order to provide women with a unique opportunity to conceive in a natural way. Besides, the components of the drug aimed at stimulation of egg maturation and usage in the fertilization process.
Clomid can be used by different types of patients, including the ones with high ranges of male hormones, as well as the ones with average estrogen levels. On the other hand, such disorders as low estrogen level, for instance, can limit the advantageous effects of Clomid, specifically if not used together with assisted reproductive technologies. Advanced Clomiphene doses are required for patients with estrogen levels lower than normal.
Following the original plan of pharmacists creating the treatment, it is administered between 3-5th days of the period. Traditionally, patients start with 50 mg Clomiphene and can increase up to 150-250 mg a day. On average, ovulation appears within 5-10 days after you stop the medicine intake. If the first therapy appeared to be ineffective, you need to start the next one with the following menstrual period. Dosage increase may be required in case the minimal dose seems to be ineffective.
According to the results of original and recent trials, such dosages are approved to be safe and completely effective. Once a patient cannot ovulate even at maximal Clomid doses, a combination of remedies may be recommended. Keep in mind that a longer than recommended therapy, as well as high doses, can activate a range of unwanted reactions and dangerous side effects. Luteal phase defects, allergic reactions and many other disorders can bother a patient, who misuses or overuses the treatment.
Nowadays, the popularity of Clomid is rapidly growing, as the drug can provide women with an ability to ovulate, conceive and give birth to a child. The only condition to achieve positive results is following safety recommendations.